Volume changes of whole brain gray matter in pediatric patients with Tourette syndrome: evidence from voxel-based morphometry
10.3760/cma.j.issn.1005-1201.2012.07.005
- VernacularTitle:应用基于体素的MR形态测量学分析抽动秽语综合征患儿脑灰质体积变化
- Author:
Yue LIU
;
Yun PENG
;
Peiyi GAO
;
Binbin NIE
;
Chuankai Lü
;
Liping ZHANG
;
Zhiying JI
;
Guangheng YIN
;
Tong YU
;
Baoci SHAN
- Publication Type:Journal Article
- Keywords:
Tourette syndrome;
Magnetic resonance imaging;
Brain
- From:
Chinese Journal of Radiology
2012;46(7):603-607
- CountryChina
- Language:Chinese
-
Abstract:
ObjectivesTo identify the related abnormalities of gray matter in pediatric patients with Tourette syndrome (TS) by using the optimized voxel-based morphometry (VBM).Methods Three dimensional T1WI was acquired in 31 TS children (28 boys,3 girts,mean age 8 years,range 4-15 years) and 50 age- and sex-matched controls on a 1.5 Tesla Philips scanner. Images were pre-processed and analyzed using a version of VBM 2 in SPM 2.The whole brain gray matter volume was compared between the study and control group by using t-test.Multivariate linear regression analysis was used for analyzing the correlation between the change of grey matter volume within each brain region (mm3 ) and YGTSS score and course of disease of TS patients.Statistical analyses were performed by using SPSS 13.0.ResultsUsing VBM,significant increases in gray matter volumes in left superior parietal lobule, right cerebellar hemisphere and left parahippocampal gyrus were detected in TS patients,and the volume changes were 4059,2126 and 84 mm3 ( t =3.93,3.71,3.58,P ＜ 0.05 ) respectively.Compared to the control group,decreased grey matter volumes were found in medulla and left pons,and the volume changes were 213 and 117 mm3( t =3.53,3.48,P ＜ 0.05 )respectively.Tic severity was not correlated with any volume changes of gray matter in brain (P ＞ 0.05,a small volume correction,KE ≥ 10 voxel).Tic course was negatively correlated with the gray matter volume of left parahippocampal gyrus ( Beta =- 0.391,P =0.039 ).ConclusionsUsing VBM technique,the gray matter abnormalities can be revealed in TS patients without obvious lesions on conventional MR imaging.The increasing volume of temporal and parietal lobes and cerebellar may be an adaptive anatomical change in response to experiential demand. The gray matter volume of the parahippocampal gyrus may be used as one potential objective index for evaluating the prognosis of TS.
