Comparison of efficacies of four different intensive insulin therapies with regard to blood-glucose control and vascular endothelial function in patients with newly-diagnosed type 2 diabetes
10.3760/cma.j.issn.1000-6699.2012.06.014
- VernacularTitle:四种胰岛素强化治疗方案对新诊断2型糖尿病患者血糖控制及血管内皮功能的影响
- Author:
Huiling SHI
;
Yan LI
;
Shanying LIU
;
Ying LIANG
;
Huisheng XIAO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Intensive insulin therapy;
Vascular endothelial function
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(6):496-498
- CountryChina
- Language:Chinese
-
Abstract:
To compare the effects of four different intensive insulin therapies on blood glucose control and vascular endothelial function in newly-diagnosed type 2 diabetes.Patients were randomly divided to accept pre-meal insulin aspart 30 or pre-meal insulin aspart and glargine at bedtime or pre-meal Novolin-R and NPH at bedtime or continuous subcutaneous insulin aspart infusion.Capillary blood glucose determination and continuous glucose monitoring system were carried out,therapeutic time and total insulin dosage were recorded.Ultrasound was used to evaluate the vascular endothelial function.Glucose level,incidence of low glucose,potency ratio of the four groups were similar( P＞0.05 ) ; FMD and NMD were not significantly improved ( P =0.718,P =0.065 ).The short-term efficacy and safety of the four groups are similar.The short-term intensive insulin therapy has no obvious effect on vascular endothelial function.
