Progress of genetic studies on serum TSH levels
10.3760/cma.j.issn.1000-6699.2012.07.021
- VernacularTitle:血清TSH水平相关的遗传学研究进展
- Author:
Ming ZHAN
;
Shuangxia ZHAO
;
Huaidong SONG
- Publication Type:Journal Article
- Keywords:
Thyroid stimulating hormone;
Susceptibility gene;
Genome-wide association study;
Polymorphism,single nueleotide
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(7):602-606
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid hormones play major roles in the regulation of a wide range of metabolie and physiologic processes.Serum thyroid-stimulating hormone( TSH ) concentration,a sensitive barometer of thyroid function,shows significant individual difference in which genetic variation is a major factor.After using traditional genetic linkage studies and candidate gene association studies to explore the suseeptibility genes of serum TSH,many progresses have been made and new susceptibility genes have been identified by genome-wide association study (GWAS).In this review,we focus on the susceptibility genes of serum TSH levels and also the future prospect that may be obtained from these studies.
