Association of single nucleotide polymorphism of interleukin 6 receptor gene and metabolic syndrome
10.3760/cma.j.issn.1000-6699.2012.07.012
- VernacularTitle:白细胞介素6受体基因多态性与代谢综合征的相关性研究
- Author:
Ming ZHANG
;
Hui CHEN
;
Tao ZHANG
;
Furong MA
;
Yifan LIU
;
Linhong TIAN
- Publication Type:Journal Article
- Keywords:
Interleukin 6 receptor;
Polymorphism,gene;
Metabolic syndrome
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(7):572-574
- CountryChina
- Language:Chinese
-
Abstract:
The association of interleukin 6 receptor ( IL-6R ) gene - 183 A/G ( rs4845617 ) and Asp358 Ala (rs8192284 A/C) polymorphisms with metabolic syndrome was investigated in Chinese Han population.The result showed that the frequencies of AA genotype and A allele were higher in patients with metabolic syndrome ( MS ) than those in healthy subjects ( P＜0.05 or P＜0.01 ).The risk of MS in patients with A allele was 1.643 folds of that with allele C(95％ CI 1.163-2.320,P＜0.01 ).No differences were found in the genotype and allele frequencies of -183A/G between two groups ( P＞0.05 ).The Asp358Ala polymorphism of IL-6R was significantly associated with MS in Chinese Han population.
