Role of oxLDL/LOX-1 system and NF-κB pathway in early diabetic vascular endothelial dysfunction

VernacularTitle:OxLDL/LOX-1系统及NF-κB通路在糖尿病血管内皮功能障碍中的作用机制
Author: Ligong ZHANG ; Lijun WANG ; Haiyan LIU ; Yonghui YU ; Yi WANG
Publication Type:Journal Article
Keywords: Diabetes mellitus; Oxidized low-density lipoprotein; Lectin-like oxidized low-density lipoprotein receptor-1; Nuclear factor-kB; Vascular endothelial dysfunction
From: Chinese Journal of Endocrinology and Metabolism 2012;28(7):589-592
CountryChina
Language:Chinese
Abstract: Diabetic rat model was established by peritoneal injection of streptozocin.At the end of 2 weeks,oxidized low-density lipoprotein (oxLDL) level in diabetic rats was raised [ ( 2.87 ± 0.40 vs 2.27 ± 0.36 ) μg/dl,P＜0.05 ] and endothelium-dependent relaxation was sluggish compared with normal rats.At the end of 6 weeks,oxLDL level continued to increase [ 4.32 ±0.66 ) μg/dl,P＜0.01] and endothelium-dependent maximum relaxation ( Rmax ) was decreased obviously ( P ＜0.01 ).Meanwhile,the protein and mRNA expressions of lectin-like oxidized lowdensity lipoprotein receptor-1 ( LOX-1 ),NF-kB,and ICAM-1 on vessel wall of diabetic rats were higher than those in normal rats,and LOX-1 mRNA was positively correlated with the levels of oxLDL,NF-kB,and ICAM-1 mRNA,while negatively correlated with Rmax,indicating that OxLDL/LOX-1 system may cause early endothelial dysfunction in diabetes via activating NF-kB and up-regulating ICAM-1 expression.