On the role of peripheral blood CD4+CD25+ regulatory T cells in the pathogenesis of Graves' disease
10.3760/cma.j.issn.1000-6699.2012.06.015
- VernacularTitle:外周血CD4+CD25+调节性T细胞在Graves病发病中的作用
- Author:
Bingbing ZHA
;
Jun LIU
;
Xiaowu HONG
;
Ying ZHA
;
Fang WANG
;
Li SHENG
;
Heyuan DING
;
Zhaoping CHEN
;
Jiong XU
- Publication Type:Journal Article
- Keywords:
Graves' disease;
CD4+ CD25+ regulatory T cells;
Foxp3
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(6):499-500
- CountryChina
- Language:Chinese
-
Abstract:
Lymphocyte subsets in peripheral blood and function of CD4+CD25+ regulatory T cells(Tregs) were assayed in patients during different periods of Graves' disease ( GD ).Breakdown of Tregs' function lead to the wild proliferation of CD4+T lymphocyte,and may play an important role in the pathogenesis of GD.It is difficult to fully restore the Tregs' function to normal after successful medication in Graves' disease,this phenomenon may lead to easy relapse of GD.
