Multivariant analysis for structural and functional changes of left ventricle in patients with lupus nephritis
10.3760/cma.j.issn.1007-7480.2012.06.007
- VernacularTitle:狼疮肾炎患者左心结构与功能改变的多因素分析
- Author:
Lina WANG
;
Meihong WANG
;
Xiaohong SANG
- Publication Type:Journal Article
- Keywords:
Lupus nephritis;
Ventricular dysfunction,left;
Cardiac structure and function
- From:
Chinese Journal of Rheumatology
2012;16(6):388-392
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the changes of left ventricle and age,duration,blood-pressure,hemoglobin,serum creatinine level and glomerular filtration rate (GFR) in lupus nephritis (LN) patients.Methods One hundred and thirty-two patients with systemic lupus erythematosus (SLE) were divided into LN group and non-LN group,the clinical data were analyzed with t test,x2 test,Pearson correlation analysis and multiple regression analysis.Results Compared with non-LN patients (4/67,6％ ),the incidence of concentric hypertrophy was significantly increased in LN patients ( 14/65,22％ ) (x2=6.790,P＜0.05 ).Left ventricular end systolic internal dimension (LVESd) was correlated positively with blood uric acid (BUA) level (B=0.014,P＜0.01 ).Left ventricular mass index (LVMI) was correlated positively with blood urea nitrogen (BUN) level (B=2.977,P＜0.01 ).lnter-ventricular septal thickness (IVST) was correlated positively with systolic blood pressure (B=0.022,P＜0.01 ).Conclusion Compared with non-LN patients,the incidence of concentric hypertrophy is significantly increased in LN patients.It may be one of the mechanisms that SLE could involve kidney,which consequently lead to hypertension,higher BUN and BUA level,which may further aggravate heart damage in turn.
