Early identification of sepsis in cancer children with neutropenia after chemotherapy

VernacularTitle:儿童恶性肿瘤化疗后中性粒细胞减少并发脓毒症的早期识别
Author: Yanwen YANG ; Ying WANG ; Jingyan TANG ; Biru LI
Publication Type:Journal Article
Keywords: Sepsis; Cancer; Neutropenia; Children
From: Chinese Pediatric Emergency Medicine 2012;19(4):383-386
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical manifestations of the febrile neutropenia cancer children,explore the relationship between the clinical data and sepsis.Methods A prospective observation study was employed,and 66 cancer children complicated with febrile and neutropenia after chemotherapy were enrolled.Sixty-six cases were divided into two groups:septic group ( n =26 ) and non-septic group ( n =40).Clinical and laboratory data were collected and compared.Results Body temperature,neutropenia duration,absolute neutrophic count ( ANC ),C-reactive protein ( CRP ),procalcitonin (PCT) and culture positive rate showed statistically differences between the septic and non-septic groups ( P ＜ 0.05 ).Body temperature ＞40 ℃,ANC ＜ 0.1 × 109/L,increases of serum CRP and PCT levels and positive culture were correlated with sepsis.Body temperature ＜ 39 ℃,neutropenia duration ＜ 5 ds,ANC ＞ 0.5 × 109/L were less correlated with sepsis.Conclusion High initial temperature,long duration of neutropenia,severely reduced ANC,increases of CRP and PCT,and culture-positive are correlated with sepsis in cancer children.