Surgical management of pancreatic neuroendocrine tumor
10.3760/cma.j.issn.1673-9752.2012.04.007
- VernacularTitle:胰腺神经内分泌肿瘤的外科治疗
- Author:
Wenhui LOU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Surgical management
- From:Chinese Journal of Digestive Surgery
2012;11(4):320-322
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic neuroendocrine tumor (pNET) accounts for about 2％ of all malignant pancreatic tumors.According to presence or absence of specific hormone related symptoms,pNET is classified as functional and non-functional.About 75％ of pNET is non-functional.Surgery is the only potential treatment that cures pNET.Before operation,localization of primary tumor is very important.For localized lesions,pancreaticoduodenectomy,segmental pancreatectomy,distal pancreatectomy or enucleation could be chosen according to the site of primary tumor.For metastatic pNET,if the primary lesion and metastatic lesions could be resected simultaneously,aggressive approach is an optimal choice and better clinical outcome could be achieved.For those with big multiple metastatic lesions,especially in the liver,debulking operation should be considered when more than 90％ metastatic lesions could be resected,for debulking operation could improve the survival and quality of life of those patients.Liver transplantation should be reserved to patients with no extra-hepatic metastasis and tumor is stable with low grade,while R0 resection could be achieved for primary lesion.
