Molecular mechanism and diagnostic principles of dementias
- Author:
Ta Van Thanh
- Publication Type:Journal Article
- Keywords:
Dementia
- MeSH:
Dementia, Diagnosis , Molecular Biology
- From:Journal of Medical Research
2005;33(1):117-121
- CountryViet Nam
- Language:Vietnamese
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Abstract:
Now a day the researchers still continue to determine whether genetic factors are the leading cause of Alzheimer disease (AD). Mutations of one in three genes (PSEN1, PSEN2, and APP) were identified causes of early AD. However, the percentage of patients with early AD is small. Although there wasn’t any genetic factors directly related to late-onset AD, in the last decades, genes of some risk factors leaded to this disease were determined more and more, especially genes caused vascular diseases. APOE was considered as highest risk factors for both of AD and vascular diseases. The risk factors of gene must be explained and put into the context of closed relations to the environment, nationality, geography and territory.
