Dosimetric study of influence of intensity modulated radiotherapy for nasopharyngeal carcinoma on hippocampal formation
10.3760/cma.j.issn.0254-5098.2012.03.019
- VernacularTitle:鼻咽癌调强放疗对海马结构的剂量影响分析
- Author:
Chenbin WU
;
Junxin WU
;
Luying XU
;
Shaojun LIN
;
Penggang BAI
;
Xiuchun ZHANG
;
Jianji PAN
- Publication Type:Journal Article
- Keywords:
Hippocampal formation;
Nasopharyngeal carcinoma;
Intensity modulated radiotherapy
- From:
Chinese Journal of Radiological Medicine and Protection
2012;32(3):297-300
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the dosimetric characteristics of hippocampal formation (HF) in the intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC).Methods Fifty-nine NPC patients underwent IMRT.Simultaneous integrated boost technology was used to determine the doses for the target areas.The dose ranges of the HF were collected by dose-volume histogram.The influence of T stage on the exposure doses ( Dmax,Dmean,D20,V10,V20,V30,and V40 ) were compared.Results The maximum dose for the HF (Dmax) ranged from 11.1 to 78.2 Gy(F =24.2,P ＜0.05) and the Dmean ranged from 3.2 to 44.6 Gy ( F =16.3,P ＜ 0.05 ).The Dmax and Dmean of the T1-2 stage patients were (40.8 ±9.4) Gy and ( 12.5 ±5.1 ) Gy,respectively,both significantly lower than those of the T3-4 stage patients [ (58.6± 14.8) Gy,(20.9± 9.3 ) Gy].The mean exposed volume of the T4 stage patients was significantly larger than that of the T1 and T2 stages patients.Conclusions In the IMRT of NPC,the HF receives rather high irradiation dose.T stage is the main factor influencing the dose,especially T3 and T4 stages deserve serious attention.
