Effects of conventional fractionated three dimensional conformal radiotherapy on unresectable hepatocelluar carcinoma
10.3760/cma.j.issn.0254-5098.2012.03.023
- VernacularTitle:常规分割三维适形放疗对不可切除的原发性肝细胞癌的疗效分析
- Author:
Genlai LIN
;
Zhaochong ZENG
;
Zheng WU
;
Qiao SUN
;
Xian ZHANG
;
Yixing CHEN
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Three-dimensional conformal;
Radiotherapy
- From:
Chinese Journal of Radiological Medicine and Protection
2012;32(3):311-313
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and toxicity of conventional fractionated three-dimensional conformal radiotherapy (3D-CRT) on unresectable hepatocelluar carcinoma(HCC).Methods Fifty two patients with unresectable HCC,all without extrahepatic metastases,were treated by 3D-CRT conducted 5 times a week with the total radiation dose of 36-66 Gy and a daily dose of 2 Gy.The curative effect was evaluated by CT scan to observe the maximum tumor size.Survival rates,survival time,and adverse responses were recorded.Results The total effective rate of the 52 patients was 69.2% with complete response (CR) in 2 patients and partial response (PR) in 34 patients.The incidence rate of radioactive hepatitis was 1.92%.The 1-,2-,3-,and 4-year survival rates were 57.7%,34.6%,23.1%,and 9.61% respectively,and the median survival time was 10.5 months.The 1-,2-,3-,and 4-year local control rates were 67%,51.5%,32.3%,and 2.24%,and the 1-,2-,3-,and 4-year distant metastasis rate were 17.2%,23.5%,36.7%,and 76.9% respectively.The intrahepatic metastases rate was 62.5% and 37.5% of the patients suffered from extrahepatic metastasis,including metastases of lung,bone,and retroperitoneal lymph nodes.The remission rate of the≥50 Gy group was 76.9%,significantly higher than that of the ≤50 Gy group (46.2%,x2 =10.72,P < 0.05 ).There was no grade 3 or 4 acute toxicity,and two patients (3.84%) developed gastric or duodenal ulcer.Conclusions Conventional fractionaled 3D-CRT evokes a rather effective response for unresectable HCC with acceptable toxicity.Radiation dose seems to be a significant prognostic factor in RT response for HCC.