The development trend of multidrug-resistant organisms
10.3760/cma.j.issn.1673-4912.2012.04.004
- VernacularTitle:多重耐药菌的发展趋势
- Author:
Yucai ZHANG
;
Liang XU
- Publication Type:Journal Article
- Keywords:
Multidrug-resistant organisms;
Development trend;
Children
- From:
Chinese Pediatric Emergency Medicine
2012;19(4):345-348
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug-resistant organisms are growing worldwide public health problem and few therapeutic options remain available.The traditional antimicrobials (glycopeptides) for multidrug-resistant Grampositive infections are declining in efficacy.New antimicrobials that are presently available are linezolid,daptomicin and tigecycline,which have well-defined indications for severe multidrug-resistant organisms infections.Unfortunately,the therapies available for multidrug-resistant Gram-negatives including carbapenem-resistant Pseudomonas aeruginosa,Acinetobacter baumannii and Enterobacteriaceae are limited to colistin and tigecycline only.Distribution of multidrug-resistant organisms are changing in recent years.Strains of multidrug-resistant organisms were dominated by Gram-negative bacteria in most hospital particularly in intensive care unit.Multidrug-resistant/pandrug-resistant Pseudomonas aeruginosa,Acinetobacter baumannii are increasing rapidly in trend.Strategy that includes surveillance,infection control procedures,isolation and antimicrobial principle should be emphasized and implemented to reduce multidrug-resistant organism diffusion.
