Clinical study of stereotactic gamma-ray body radiation therapy for patients with stage Ⅰ / Ⅱ nonsmall cell lung cancer
10.3760/cma.j.issn.1004-4221.2012.04.009
- VernacularTitle:体部伽马刀治疗早期非小细胞肺癌临床观察
- Author:
Hongqi LI
;
Yingjie WANG
;
Ping LI
;
Xuan WANG
;
Jing LI
;
Weizhang WU
;
Tingyi XIA
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small lung/radiotherapy;
Radiotherapy,stereotactic gamma-ray body;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2012;21(4):321-324
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo further evaluate the value of the stereotactic gamma-ray body radiation therapy ( γ-SBRT ) for patients with stage Ⅰ / Ⅱ non-small cell lung cancer ( NSCLC ) basing on the preliminary studies.MethodsTwenty-nine eligible patients with stage Ⅰ / Ⅱ NSCLC who is unable or unwilling to receive surgery underwent treatment prospectively with γ-SBRT (OUR-QGD).Patients were fixed by vacuum bag.Each patient underwent slow CT simulation at 5 s/slide with thickness of 5 mm and interval of 5 mm to take into consideration tumor motion.A total dose of 50 Gy was delivered at 5 Gy/fraction to 50％ isodose line covering 100％ of the PTV,with 60 Gy at 6 Gy/fraction to 60％ isodose line covering 90％ of the CTV,70 Gy at 7 Gy/fraction to 70％ isodose line covering 80％ of the GTV,and 10 times finished in 2 weeks,5 fractions per week.ResultsThe follow-up rate was 97％.The 6 month local tumor response rate was 93％,with CR 86％,and PR 7％.The 1-,2-year local control rates were both 93％.The 1-,2-year overall survival rates for the whole group,stage Ⅰ and stage Ⅱ were 97％ and 89％,100％ and 92％,67％ and 67％,respectively.The 1-,2-year progression-free survival were 90％ and 86％,respectively.34％ of the patients had acute radiation toxicities ( grade 1,2 and 3 in 6,2 and 2patients,respectively),and 38％ late radiation toxicities ( grade 1 and 2 in 10 and 1,patients).Conclusions γ-SBRT is a safe and effective treatment regimen,resulted in promising local control and survival with minor toxicity.
