Effects of continuous wound infusion of ropivacaine for postoperative analgesia on local inflammation

VernacularTitle:持续切口灌注罗哌卡因术后镇痛对局部炎症反应的影响
Author: Weiqing ZHANG ; Zhengzuo WAN
Publication Type:Journal Article
Keywords: Drug delivery systems; Amides; Pain,postoperative; Analgesia; Inflammation
From: Chinese Journal of Anesthesiology 2012;32(4):430-432
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of continuous wound infusion of ropivacaine for postoperative analgesia on local inflammation.Methods Forty ASA Ⅰ or Ⅱ patients,aged 45-64 yr,weighing 45-80 kg,undergoing simple nephrectomy,were randomized into either continusous wound infusion of local anesthetic group ( group CWI ) or control group ( group C),with 20 cases each.Group CWI were treated with continuous wound infusion of 0.25％ ropivacaine for postoperative analgesia,while group C were infused with the same volume of normal saline.All patients received patient-controlled analgesia with intravenous morphine.At 6,12,24 and 48 h after operation,the accumulated consumption of morphine was documented,and the concentration of prostaglandinE2 (PGE2) of drainage was determined using ELISA.Results Compared with group C,the accumulated consumption of morphine was decreased,and the PGE2 concentration was decreased in group CWI at each time points.Conclusion The mechanism of postoperative analgesic effect of continuous wound infusion of ropivacaine is related to the suppression of local inflammation in wound sites.