The effect of simvastatin on the level of serum adiponectin and asymmetric dimethylarginine in patients with acute stroke
10.3760/cma.j.issn.1673-4904.2012.22.003
- VernacularTitle:辛伐他汀对急性脑卒中患者血清脂联素和不对称性二甲基精氨酸水平的影响
- Author:
Chunling YANG
;
Chunjian DUAN
;
Feixue LIU
;
Dan WANG
;
Dongxia WANG
;
Li YAN
;
Xingbin WANG
;
Fengling SHI
;
Mei JIN
;
Yucheng WANG
- Publication Type:Journal Article
- Keywords:
Cerebrovascular accident;
Adiponectin;
Simvastatin;
Asymmetric dimethylarginine
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(22):8-10
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the effect of simvastatin on the level of serum adiponectin and asymmetric dimethylarginine (ADMA) in patients with acute stroke.MethodsNinety patients with acute stroke were selected and divided by random digits table method into common treatment group and intervention treatment group with 45 cases each.The volume of cerebral infarction and the evaluation score of clinical neurological impairment degree were calculated.The levels of serum adiponectin and ADMA before and after treatment were detected by erzyme-linked immunosorbent assay.The changes of serum adiponectin and ADMA before and after treatment in two groups were compared and their correlations with the volume of cerebral infarction and the evaluation score of clinical neurological impairment degree were analyzed.Results The level of serum adiponectin and ADMA in two groups before treatment had no statistical differences (P ＞ 0.05 ).The levels of serum adiponectin in two groups after treatment increased and ADMA decreased significantly,which had significant differences compared with those before treatment ( P ＜ 0.05 ).The level ofserum adiponectin in intervention treatment group was significantly higher than that in common treatment group and ADMA was obviously lower than that in common treatment group after treatment [(5.92 ± 0.15)mg/L vs.( 4.51 ± 0.13 ) mg/L,( 0.96 ± 0.13 ) μ mol/L vs.( 1.08 ± 0.15 ) μ mol/L ] ( P ＜ 0.05 ).Rank correlation analysis showed that the level of serum adiponectin before treatment was negatively correlated with the volume of cerebral infarction and the evaluation score of clinical neurological impairment degree ( r ＝ -0.75,-0.59,P ＜ 0.05).The level of ADMA before treatment was positively correlated with the volume of cerebral infarction and the evaluation score of clinical neurological impairment degree ( r =0.68,0.71,P ＜ 0.05 ).Conclusion Simvastatin can increase the level of serurm adiponectin and decrease the level of ADMA efficiently in patients with acute stroke,and improve the prognosis of the patients.
