Expression and clinical significance of vascular endothelial growth factor in serum of patients with carotid artery stenosis
10.3760/cma.j.issn.1673-4904.2012.22.010
- VernacularTitle:血管内皮生长因子在颈动脉狭窄患者血清中的表达及临床意义
- Author:
Fuyong LI
- Publication Type:Journal Article
- Keywords:
Carotid stenosis;
Vascular endothelial growth factors;
Cerebrovascular accident
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(22):30-32
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the changes and clinical significance of vascular endothelial growth factor (VEGF) in senum of patients with carotid artery stenosis (CAS).MethodsThe serum VEGF level of72 CAS patients (CAS group) and 30 normal persons (control group) were detected by double antibody sandwich enzyme linked immunosorbent assay(ELISA).The patients in CAS group were divided into A group (CAS＜50％,23 cases),B group (50％ ≤CAS ＜75％,30 cases) and C group (CAS≥75％,19 cases)according to the degree of CAS.The risk factors of CAS were analyzed.ResultsThe incidence of hypertension,hyperlipidemia,diabetes in CAS group were significantly higher than those in control group[69.44％(50/72)vs.36.67％(11/30),63.89％(46/72) vs.43.33％(13/30),50.00％(36/72) vs.23.33％(7/30)] (P＜0.05).The serum VEGF level in control group,A group,B group and C group were (0.59 ± 0.20),(0.91 ± 0.30),(2.96 ± 0.99) and (5.87 ± 1.96) ng/L,respectively.Compared with those in control group,the serum VEGF level in A,B,C group increased significantly (t =4.147,8.746,5.332,P ＜ 0.05 ).The serum VEGF level among A,B,C group had statistical difference:C group ＞ B group ＞ A group (F=27.683,P ＜ 0.05 ).The serum VEGF level and the carotid stenosis degree had significantly positive correlation (r =0.875,P＜0.05 ).ConclusionsThe serum VEGF level has high expression in patients with CAS.The high level of serum VEGF may be one of the risk factors of the occurrence and development of CAS.
