Influence of dexmedetomidine on median effective target effect-site concentration of sufentanilinhibiting urethroscope insertion response hn patients undergoing transurethral resection of prostate
10.3760/cma.j.issn.1673-4904.2012.21.004
- VernacularTitle:右美托咪定对舒芬太尼抑制经尿道前列腺电切术患者尿道镜置入反应半数有效效应室靶浓度的影响
- Author:
Weimin ZHOU
;
Jianjun LI
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Sufentanil;
Drugdeliverysystems;
Dose-responserelationship;
drug;
Transurethral resection of prostate
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(21):11-13
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To evaluate the influence of dexmedetomidine on median effective target effect-site concentration(EC50)of sufentanil-inhibiting urethroscope insertion response in patients undergoing transurethral resection of prostate(TURP).[Methods] Forty patients with ASA grading Ⅰ-Ⅱ who accepted selective TURP were divided by random digits table method into two groups with 20 cases each.The patients in dexmedetomidine group were treated with 0.6 μ g/kg dexmedetomidine intravenous infusion for more than 10 min,while control group were treated with equivalent capacity of 0.9％ sodium chloride.At 5 min after stopping injection,target-controlled infusion of propofol was started and the plasma target concentration was 3.0 μ g/ml.At 10 min after infusion,target-controlled infusion of sufentanil began and the plasma target concentration was 0.20 ng/ml.The target concentration of sufentanil of the next patient accorded to the patient with or without the urethroscope insertion response and the adjacent rate of the target concentration was 1.1.The EC50 and 95％ confidence interval(CI)of sufentanil were calculated.[Results] There were 20 cases in dexmedetomidine group ultimately selected and 19 cases in control group.There was no statistical significance in absolute value of ST segment of intraoperative electrocardiogram,systolic blood pressure,heart rate,pulse oxygen saturation and bispecual index between two groups(P＞0.05).EC5o of sufentanil-inhibiting urethroscope insertion response in dexmedetomidine group was 0.1148 ng/ml(95％ CI 0.1055-0.1249 ng/ml),which was significantly lower than that in control group[0.1454 ng/ml(95％ CI 0.1339-0.1580 ng/ml)](P＜0.05).[Conclusions] 0.6 μg/kg dexmedetomidine intravenous infusion before operation can reduce the EC50 of sufentanil-inhibiting urethroscope insertion response in patients undergoing TURP.
