Significance of the high-risk human papilloma virus detection in the screening and diagnosis of cervical lesions
10.3760/cma.j.issn.1673-4904.2012.21.003
- VernacularTitle:高危型人乳头瘤病毒检测在宫颈病变筛查及诊断中的意义
- Author:
Na GAO
;
Jun ZHENG
;
Hong SHI
;
Tao WU
- Publication Type:Journal Article
- Keywords:
Uterine cervical diseases;
Human papillomavirus;
Cervical screening
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(21):7-10
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the significance of the high-risk human papilloma virus (HPV)detection in the screening and diagnosis of cervical lesions.[Methods] The high-risk HPV DNA test results of 797 patients with cervical lesions who all accepted cytology and histopathology test were collected and analyzed retrospectively.[Results]The high-risk HPV DNA positive rates in cervicitis,cervical intraepithelial neoplasia(CIN)Ⅰ,CIN Ⅱ,CIN Ⅲ and cervical cancer were 53.41％(188/352),70.91％(117/165),87.63％(85/97),97.90％(140/143),97.50％(39/40),respectively.The sensitivity and negative predictive value of the high-risk HPV DNA detection for CIN Ⅱ and more serious lesions were 96.66％(318/329),93.29％(153/164),respectively.The detection rate of CIN Ⅱ and more serious lesions in patients with atypical squamous cells of undetermined significance(ASCUS)and positive high-risk HPV DNA was 30.03％(94/313),while the rate in patients with negative high-risk HPV DNA was 1.55％(2/129).[Conclusions] The more serious the cervical lesion is,the higher high-risk HPV DNA positive rate is.It is most closely related with CIN 11 and cervical cancer.The high-risk HPV DNA detection has high sensitivity and negative predictive value for CIN Ⅱ and more serious lesions.The high-risk HPV DNA detection has high negative predictive value in CIN Ⅱ and more serious lesions in ASCUS.
