Clinical application of INRatio coagulometer for fast measuring international normalized ratio
10.3760/cma.j.issn.1673-4904.2012.24.006
- VernacularTitle:INRatio快速血凝分析仪检测国际标准化比值的临床应用价值
- Author:
Yanping YIN
;
Xinchun YANG
;
Jing XUE
- Publication Type:Journal Article
- Keywords:
Warfarin;
International normalized ratio;
Blood coagulation
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(24):14-17
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the correlation and agreement of international normalized ratio (INR) measured by INRatio coagulometer and standard laboratory venous blood measurement in order to judge the clinical application value of measuring INR by INRatio coagulometer.MethodsOne hundred who received warfarin were chosen randomly.Venous blood and finger capillary blood were taken simultaneously for measurement of INR by laboratory coagulation analyzer SYSMEX CA-7000 and INRatio coagulometer respectively.The correlation and agreement of INR results tested by the two methods were analyzed.Results When INR ≤5,there was a good correlation between INRatio coagulometer and laboratory coagulation analyzer SYSMEX CA-7000 (r =0.898,P =0.000).The mean bias of the two methods was 0.36 and INR measured by INRatio coagulometer were higher than those tested by laboratory coagulation analyzer SYSMEX CA-7000.By Bland-Altman,it showed a good agreement for 91.2％ (62/68) of the difference INR located 95％ the limited of agreement when the mean INR 1.60 - 3.50,and a bad agreement for only 50.0％(1/2) of the difference INR located 95％ the limited of agreement when the mean INR ＞ 3.50.ConclusionsIn the therapeutic range,INR measured by INRatio coagulometer shows a good correlation and agreement with INR measured by the established laboratory method.INRatio coagulometer can be used to monitor INR in the patients received oral anticoagulant therapy.
