Efficacy of ramosetron in the prevention of postdelivery nausea and vomiting during emergency cesarean delivery

VernacularTitle:雷莫司琼预防急诊剖宫产术中恶心呕吐的临床效果
Author: Xiaojian LI ; Xia CHEN ; Ying HAN
Publication Type:Journal Article
Keywords: Cesarean section; Postpartum vomiting
From: Chinese Journal of General Practitioners 2012;11(8):603-604
CountryChina
Language:Chinese
Abstract: We sought to determine the efficacy of ramosetron in the prevention of nausea and vomiting during emergency cesarean delivery under spinal anesthesia with strict controls of causative factors.A total of 206 parturients participated in a randomized,single-blind and placebo-controlled trial.They received an intravenous injection of either ramosetron 0.3 mg or normal saline immediately after cord clamping.The primary outcome was the presence of postdelivery nausea and vomiting.Secondary outcomes included the need for rescue antiemetic,hypotension,pain and adverse effects.The incidence of postdelivery nausea and vomiting was 10.7％ in the ramosetron group vs.28.2％ in the control group (P ＜ 0.01 ).The incidence of intraoperative hypotension and postdelivery was similar in both groups.The incidence of postdelivery pain and the requirement for rescue antiemetic were similar in both groups.Ramosetron 0.3 mg is effective in the prevention of postdelivery nausea and vomiting during cesarean delivery.