Final height outcome of boys with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analogue
10.3760/cma.j.issn.1000-6699.2012.07.007
- VernacularTitle:促性腺激素释放激素治疗改善特发性中枢性性早熟男孩的成年身高
- Author:
Pimei ZHENG
;
Zhe SU
;
Huamei MA
;
Minlian DU
;
Qiuli CHEN
;
Yanhong LI
;
Hongshan CHEN
- Publication Type:Journal Article
- Keywords:
Gonadotropin-releasing hormone;
Puberty,precocious;
Adult height
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(7):551-556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the final adult height of 20 boys with idiopathic central precocious puberty (ICPP) treated with slow-releasing gonadotropin-releasing hormone analogue(GnRHa).Methods Twenty boys with ICPP were treated with GnRHa for( 20.0 ± 6.1 ) months.At the beginning of therapy,mean chronological age and bone age was( 11.4 ± 1.0 ) years and ( 13.0 ± 0.4 ) years,respectively,GnRHa was discontinued when the boys reached the chronological age and bone age of( 13.2 ± 1.1 ) years and ( 13.7 ± 0.6 ) years,respectively.After the end of treatment,all the boys had been followed up for( 3.3 ± 1.5 ) years and had achieved adult height.Comparisons were made among their predicted adult height ( PAH ),final adult height ( FAH ),and target height ( THt ).The long-term outcome of final adult height in boys with ICPP was investigated after GnRHa treatment.Results All the boys reached target height range.Final height was similar to the target height [ ( 169.8 ± 5.8 vs 167.8 ± 4.6 ) cm,P＞0.05 ].The height gain,defined as the difference between predicted adult height at the start of treatment using the height SDS for bone age and actual adult height was( 3.62 ± 3.57 ) cm with the residual growth capacity of ( 11.82 ±3.99)cm,PAH significantly improved after GnRHa treatment compared with before treatment [ ( 169.0 ± 5.0 vs166.2 ± 4.2 ) cm,P＜0.01 ].There were no differences among PAH,FAH,and THt.Conclusion GnRHa treatment improves final height within the range of target height in boys with central precocious puberty.
