Association between mitochondrial uncoupling protein 2 gene promoter -866G＞A polymorphism and ischemic stroke in diabetic patients

VernacularTitle:线粒体解耦联蛋白2基因启动子-866G＞A多态性与2型糖尿病缺血性脑卒中的相关性研究
Author: Bing GU ; Jinrong QIU ; Qian ZHU ; Lu ZHANG ; Yi CHAI
Publication Type:Journal Article
Keywords: Uncoupling protein 2; Polymorphism,gene; Diabetes mellitus,type 2; Stroke,ischemic
From: Chinese Journal of Endocrinology and Metabolism 2012;28(7):561-564
CountryChina
Language:Chinese
Abstract: Objective To investigate the association of uncoupling protein 2 ( UCP-2 ) gene promoter -866G＞A polymorphism and ischemic stroke in diabetic patients.Methods A total of 844 type 2 diabetic patients including 404 cases with ischemic stroke and 440 cases without ischemic stroke were selected for the 4 year prospective study,Genomic DNA was extracted from the whole blood samples of subjects,UCP-2 gene promoter -866G ＞ A polymorphism was detected by TaqMan MGB probe method,and then the genotype and allele gene frequencies were compared.Results The risk of ischemic stroke in type 2 diabetic female patients with AA+GA genotypes of UCP-2 was higher than that with GG genotype (P＜0.05),but there was no difference among male patients with three genotypes.Conclusions UCP-2 gene promoter -866G ＞ A polymorphism increases the risk of ischemic stroke in Chinese diabetic women.