The expression of Survivin,PTEN in tongue squamous cell carcinoma and the correlation with vascular endothelial growth factor and its clinical significance
10.3760/cma.j.issn.1673-4904.2012.18.001
- VernacularTitle:Survivin、PTEN在舌鳞状细胞癌中的表达及其与血管内皮生长因子的相关性和临床意义
- Author:
Yong JIANG
;
Qingliang FENG
;
Cong ZHU
- Publication Type:Journal Article
- Keywords:
Tongue neoplasms;
Vascular endothelial growth factor A;
Survivin;
PTEN
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(18):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression of Survivin,PTEN in tongue squamous cell carcinoma (TSCC) and the correlation with vascular endothelial growth factor (VEGF) and its clinical significance.Methods The expression of Survivin,PTEN and VEGF of 72 TSCC samples and 15 normal tongue mucosa (NTM) samples were detected by immunohistochemical method.Results The positive expression rate of Survivin,PTEN and VEGF in TSCC were 66.7％(48/72),61.1％(44/72),70.8％(51/72)respectively,while the positive expression rate in NTM were 0,100.0％ (15/15),0.There were statistical significance between the rate in TSCC and NTM respectively (P ＜0.01 ).The expression of Survivin and VEGF in TSCC were positively correlated with TNM stage,histological grade and lymph node metastasis (P＜ 0.05 or ＜ 0.01 ),while the expression of PTEN had negative correlation with them (P＜ 0.05 or ＜ 0.01 ).The expression of Survivin was positively correlated with VEGF expression in TSCC (r=0.6482,P＜0.01),while the expression of PTEN was negatively correleted with VEGF expression (r =-0.4027,P ＜0.01).Conclusions The expression of Survivin and PTEN in TSCC are associated with tumor occurrence and development closely,and are both significantly correlated with VEGF.Joint detection of Survivin,PTEN and VEGF have important reference value in clinical diagnosis,metastasis and prognosis of TSCC.
