Relationship between anti-oncogene mutation and microsatelite instability in gastrointestinal stromal tumor
10.3760/cma.j.issn.1673-4203.2012.07.012
- VernacularTitle:肿瘤抑癌基因突变与MSI相关性在胃肠道间质瘤中的研究进展
- Author:
Guangyao WANG
;
Ping CHEN
;
Liang ZONG
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Genes,Suppressor;
Mutation
- From:
International Journal of Surgery
2012;39(7):468-471
- CountryChina
- Language:Chinese
-
Abstract:
By now,the mutations of C-KIT gene and PDGFRA have been regarded as the most important primary incidences.The latest results have revealed the fact that the abnormal expressions of p53,p16,p21 WAF-1,p27 and E-cadherin(cDH1) which were labeled as anti-oncogenes in most of human tumors,existed in the progression of gastrointestinal stromal tumor.Therefore,we put forward the theory that gene mutaion may lead to the instability of DNA that further promotes mutation of short tandem repeat in anti-oncogene coding region,on basis of which,that finally lead to the malignant progession of gastrointestinal stromal tumor by anti-oncogene mutation.
