Comparison of other cancers in Chinese han women with familial and sporadic breast cancer
10.3760/cma.j.issn.1673-4203.2012.07.010
- VernacularTitle:中国汉族女性家族性和散发性乳腺癌患者家系中其他肿瘤的比较
- Author:
Jing LIU
;
Juan ZHANG
;
Tao OUYANG
;
Jinfeng LI
;
Tianfeng WANG
;
Zhaoqing FAN
;
Tie FAN
;
Benyao LIN
;
Yuntao XIE
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Familial;
Epidemidogy;
Ethmicgroups
- From:
International Journal of Surgery
2012;39(7):461-464
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the family history of other cancers in Chinese han women with familial or sporadic breast cancer.Methodswe analyzed the clinical date of 4 847 primary breast cancer patients cancer patients were treated at the Breast Cancer,Peking University Cancer Hospital between October 2003 and February 2011,among them,465 were familial and4 382 were sporadic breast cancer patients.The differences of family history of cancers other than breast or ovarian cancers were compared between the patients with familial breast cancer and sporadic breast cancer.Results The proportion of cancers other than breast or ovarian cancers in familial breast cancer patients was significantly higher than that in sporadic breast cancer patients(29.7％ vs 20.8％,odds ratio 1.61,P＜ 0.001).Furthermore,the proportion in pancreatic cancer,prostate cancer,and renal cancer in familial breast cancer patients was significantly higher than that of sporadic breast cancer patients ( pancreatic cancer:2.2％ vs 0.8％,P =0.002 ; prostate cancer:1.5％ vs 0.3％,P ＜ 0.001 ; renal cancer:1.1％ vs 0.4％,P =0.03,respectively).And the relative risks of pancreatic cancer,prostate cancer,and renal cancer in the familial breast cancer patients were 2.90-fold,6.07-fold,and 2.97-fold higher than that of sporadic breast cancerpatients,respectively.ConclusionsOur results suggest that the relative risk of cancer other than breast or ovarian in familial breast cancer patients is significantly higher than that in sporadic breast cancer patients,especially pancreatic cancer,prostate cancer,and renal cancer.
