Influence of hypoxic preconditioning on liver cancer hepatectomy
10.3760/cma.j.issn.1673-4203.2012.07.015
- VernacularTitle:低氧预适应对肝切除后肝保护作用的分子机制
- Author:
Pengfei LI
;
Peijian ZHANG
;
Xiaofan HAN
- Publication Type:Journal Article
- Keywords:
Anoxia;
Adaptation,physiological;
Hepatic neoplasms;
Hepatectomy
- From:
International Journal of Surgery
2012;39(7):478-480
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxic preconditioning improves organism in stress response such as operation.This dissertation expound the effects of hypoxic preconditioning on hepatic carcinoma after hepatic resection.Hypoxic preconditioning protect remainder hepatocyte from ischemia reperfusion injury in the remaining liver by regulating HIF-1,nuclear factor-kappa B and being kind to our mitochondria; remote-ectopic hypoxic preconditioning and cross-pluripotential hypoxic preconditioning preserve residual liver.Hypoxic preconditioning can relieve liver from ischemia reperfusion injury after hepatocellular carcinoma hepatectomy,but no clear evidence demonstrate it improve residual liver regeneration.This need further experimental study.
