Pregnane X receptor and tumor multidrug resistance
10.3760/cma.j.issn.1673-422X.2012.07.003
- VernacularTitle:孕烷X受体与肿瘤多药耐药的相关性
- Author:
Enqi QIAO
;
Jinhai TANG
;
Jianzhong WU
- Publication Type:Journal Article
- Keywords:
Drug resistance;
neoplasm;
P-glycbprotein;
Pregnane X receptor
- From:
Journal of International Oncology
2012;39(7):489-492
- CountryChina
- Language:Chinese
-
Abstract:
The overexpression of P-glycoprotein(P-gp)and its coding gene mdrl is regarded as the classic mechanism of muhidrug resistance(MDR).Recent studies find that pregnane X receptor(PXR)can mediate the expression of P-gp.It is confirmed that PXR can also inhibit apoptosis of tumor cells.Therefore,preventing the activation of PXR specifically may be a new method to prevent MDR.
