Clinical significance of lndoleamine 2,3-dioxygenase (IDO) and B7-H1 expressions in pancreatic carcinoma patients undergone pancreatoduodenectomy

VernacularTitle:吲哚胺2,3-双加氧酶和B7分子同源蛋白1在胰腺癌组织中的表达及其临床意义
Author: Liancai WANG ; Qingyong MA ; Deyu LI ; Xiangli CHEN ; Haibo YU ; Chunhui GAO ; Kun GUO
Publication Type:Journal Article
Keywords: Gene expression; Pancreatic neoplasms; Pancreaticoduodenectomy; Prognosis
From: Chinese Journal of Hepatobiliary Surgery 2012;18(7):503-507
CountryChina
Language:Chinese
Abstract: ObjectiveTo analyze the relationship between expressions of Indoleamine 2,3-dioxygenase (IDO) and B7-H1 with clinico-pathological features and their prognostic significance in pancreatic cancer (PC).Method95 patients who underwent radical pancreaticoduodenectomy for PC were studied.The IDO and B7-H1 expressions in tissue specimens were determined by immunohistochemistry.ResultsIDO and B7-H1 expressions were higher in pancreatic carcinoma tissues than in normal pancreatic tissues (P＜0.05).IDO and B7-H1 expressions positively and significantly correlated with pathological grades and tumour-node-metastasis (TNM) stages (P＜0.05).They were prognostic of poor cancer-specific survival.After adjusting by the Cox proportional hazards regression models (P＜0.05),only a combined IDO/B7-H1 expression served as an independent prognostic marker.ConclusionsIDO and B7-H1 were expressed in PC,and they were important markers for malignant progression of PC.A combined IDO/B7-H1 expression served as an independent prognostic marker for PC.