The experience of the diagnosis and treatment of graft-versus-host disease after liver transplantation in 4 case
10.3760/cma.j.issn.1007-8118.2012.07.011
- VernacularTitle:肝移植术后移植物抗宿主病的临床诊治经验:附四例报道
- Author:
Lu WANG
;
Dongdong LIN
;
Wei LAI
;
Menglong WANG
;
Shichun LU
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Graft-versus-host disease
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(7):529-531
- CountryChina
- Language:Chinese
-
Abstract:
ObsjectiveTo investigate the clinical data,and to summarize the clinical experience of diagnosis and treatment of graft-versus-host-disease (GVHD) after liver transplantation.Methods 4 of 480 recipients undergone liver transplantation developed GVHD from Apr.2005 to Sep.2011.The 4 recipients'clinical courses and laboratory tests were recorded.ResultsThe diagnosis of GVHD depended on clinical syndrome involved skin rash,bone marrow depression and diarrhea.Skin biopsy and STR-PCR were matched.Among them,2 with successful treatment have been surviving for 7 and 24 months,and 2 died from infection.One recipient had the donor T lymphocyte microchimerism detected by STR-PCR.ConclusionsGVHD after liver transplantation can cause high mortality due to bone marrow depression.A reasonable treatment can be to reduce immunosuppressant and glucocorticoids and IVIG.
