Association between nitrotyrosine and coronary heart disease in type 2 diabetes

VernacularTitle:硝基酪氨酸与2型糖尿病冠心病的关系研究
Author: Jinying ZHU ; Huijuan ZHANG ; Xiaoyan JIANG ; Hui ZHOU ; Wenfang HUA ; Zhijie LIU ; Fei HAO ; Qiuxia YU
Publication Type:Journal Article
Keywords: Nitrotyrosine; Type 2 diabetes mellitus; Coronary heart disease
From: Clinical Medicine of China 2012;28(7):676-678
CountryChina
Language:Chinese
Abstract: Objective To investigate the association of nitrotyrosine with coronary heart disease (CHD) in type 2 diabetes mellitus.Methods The nitrotyrosine levels were determined in 109 patients of type 2 diabetes mellitus without CHD (T2DM).One hundred and fifty-two patients of type 2 diabetes mellitus with CHD (T2DM-CHD) and 103 healthy control subjects by ELISA.Results T2DM-CHD patients had significantly increased nitrotyrosine compared with T2DM group and the control group [ ( 78.17±10.68 )nmol/L,(70.50 ± 9.13) nmol/L vs ( 63.23 ± 11.55 ) nmol/L,Ps ＜ 0.01 ].Nitrotyrosine was correlated with total cholesterol,triglyceride,fasting glucose and Gensini Score (r=0.361,P=0.009;r =0.206,P=0.001 ;r=0.347,P=0.026; r=0.466,P ＜ 0.001 ).Multivariable logistic regression showed nitrotyrosine was independently associated with CHD combined with type 2 diabetes mellitus ( OR=1.094,95％ CI:1.053-1.137 ; P ＜ 0.01 ).Conclusion Nitrotyrosine plays an important role in the formation and development of cardiovascular disease in tvoe 2 diabetes.