Preliminary study of adjuvant therapy with autologous platelet-rich gel for refractory wound

VernacularTitle:自体富血小板凝胶换药辅助治疗难愈合创面初步探讨
Author: Xiaodong ZHANG ; Tiebing QU
Publication Type:Journal Article
Keywords: Platelet-rich plasma; Skin ulcer; Wound healing
From: Chinese Journal of Trauma 2012;28(7):658-660
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of autologous platelet-rich plasma in the treatment of refractory wound.Methods Fifteen cases with refactory wound ( 1 1 males and 4 females) involving six cases with diabetic ulcer,five with post-surgical ulcer wounds and four with pressure sore were enrolled into the study.The autologous platelet-rich gel was applied to the wounds after debridement and dressing change was done every week.The results of wound bacterial culture were regularly detected and the growth of granulation was observed.Skin graft or flap graft surgery was performed to close the wound when the wound condition was permitted.Results Of all,three patients had spontaneous healing after the change of dressing,four got healing after flap graft and eight attained healing after skin graft.There was no recurrence or sinus after treatment.Conclusion Autologous platelet-rich gel accelerates wound healing,improves wound condition,and raises success rate of surgical closure of the wound.