Role of microRNA in pathogenesis, progression, diagnosis and treatment of hepatocellular carcinoma
10.3760/cma.j.issn.1673-4203.2012.07.017
- VernacularTitle:microRNA在肝细胞癌发生发展及诊治中的作用
- Author:
Lei YIN
;
Aijun LI
;
Weiping ZHOU
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocelluar;
MicroRNAs;
Oncogenes;
Genes,suppressor
- From:
International Journal of Surgery
2012;39(7):485-488
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA (miRNA) is a class of endogenous,single-stranded non-coding small RNA that contains 21 to 23 nucleotides and is widely distributed in eucaryon,miRNA plays an important regulatory role in cell proliferation,apoptosis,growth and development through the regulation of gene translation after transcription and expression,miRNA has a close relationship with pathogenesis and development of hepatocellular carcinoma.And in this process,part of miRNA acts as oncogenes or tumor suppressor genes.A number of miRNA,such as miR-30d,miR-221,miR-222 and miR-101,had been found to express abnormally in hepatoeellular carcinoma.Here we summarize the related progress in research of miRNA and hepatocellular carcinoma.
