Follow-up study on hepatitis B virus mother-to-child transmission in 1355 HBsAg-positive pregnant women
10.3760/cma.j.issn.1000-6680.2012.06.006
- VernacularTitle:HBsAg阳性的1355名孕妇乙型肝炎病毒母婴传播的随访调查
- Author:
Jing ZHOU
;
Yuzhu YIN
;
Lingling WU
;
Peizhen ZHANG
;
Xiaomao LI
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Hepatitis B surface antigens;
Disease transmission,Vertical;
Fetal Diseases;
Immunoglobulins;
Vaccination
- From:
Chinese Journal of Infectious Diseases
2012;30(6):343-348
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate hepatitis B virus (HBV) mother-to-child transmission rate in hepatitis B virus surface antigen (HBsAg)-positive pregnant women.MethodsA total of 1355 HBsAg-positive pregnant women and their 1360 newborns (included 5 twins)were collected prospectively.All newborns received hepatitis B immunoglobulin (HBIG) 200 U intramuscularly within 6 hours of birth as early as possible,and were administered with routine 10 μg recombinant hepatitis B vaccine (at 0,1,6 months of birth).The venous blood HBV markers and HBV DNA levels were detected in all newborns at 0,7,12 months of age.The measurement data were analyzed by t test.Qualitative data were analyzed by chi square test,rank sum test or Fisher exact test.Results The intrauterine HBV infection rate of 1360 infants were 1.54％ (21/1360) during 12 months of follow-up.The rate of intrauterine infection in HBeAg positive mothers was significant higher than that of HBeAg negative mothers (4.44％ vs 0,χ2 =35.99; P＜0.05); the rate of intrauterine infection in HBV DNA positive mothers was significant higher than that of HBV DNA negativemothers (3.13％ vs 0,χ2 =21.84; P＜0.05).When maternal serum HBV DNA≥1 × 107 IU/mL,the rate of intrauterine infection was 6.01 ％,which was significantly higher than that of maternal serum HBV DNA＜ 1 × 107 IU/mL (χ2 =39.43,P＜0.05).ConclusionsAfter strict combined active-passive immunization,the rate of HBV intrauterine infection is 1.54％.When mothers are HBeAg positive or with high level of HBV DNA,the rate of HBV intrauterine infection increases significantly.Intrauterine infection is the main cause of failure in immunoblockade of HBV mother-to-child transmission.
