Evaluation of color Doppler ultrasound of renal blood flow combined with the detection of bone morphogenetic protein-7 in early diagnosis of type 2 diabetic nephropathy
10.3760/cma.j.issn.1004-4477.2012.07.012
- VernacularTitle:肾血流彩色多普勒检测与骨形态发生蛋白-7检测在2型糖尿病肾病早期诊断中的价值
- Author:
Zhijie ZHANG
;
Ning YU
;
Zhengbin WANG
;
Zhimei YAN
;
Dongmei MENG
;
Ronggui LIU
;
Zhaoyan DING
;
Fengfeng SHI
- Publication Type:Journal Article
- Keywords:
Ultrasonography,Doppler,color;
Diabetic nephropathies;
Kidney;
Hemodynamic phenomena;
Bone morphogenetic proteins
- From:
Chinese Journal of Ultrasonography
2012;(7):591-594
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the significance of color Doppler ultrasound examination of renal blood flow combined with the detection of bone morphogenetic protein-7(BMP-7)in early diagnosis of type 2 diabetic nephropathy.Methods Blood BMP-7 level was tested in 90 patients with type 2 diabetic nephropathy and 30 controls,and parameters of renal blood flow were measured by color Doppler ultrasound examination.Blood BMP-7 level as well as resistant index(RI)of segmental renal artery(SRA)and interlobar renal artery(IRA),were compared between these two groups.Results Compared with controls,blood BMP-7 level gradually decreased with the aggravation of diabetic kidney damage(P＜0.01).The peak systolic velocity(Vmax)and the end diastolic velocity(Vmin)of SRA and TRA were slowed gradually,while RI increased(P＜0.01).Blood BMP-7 level was negatively correlated with IRA's and SRA's RI of IRA and SRA(r =-0.603,P＜0.01;r =-0.652,P＜0.01).Conclusions Color Doppler ultrasound examination of renal blood flow combined with detection of BMP-7 might play an important role in early diagnosis of type 2 diabetic nephropathy.
