Treatment of ketamine-associated bladder dysfunction with bladder hydrodistention

VernacularTitle:膀胱水扩张术治疗氯胺酮相关性膀胱损害六例分析
Author: Yongda LIU ; Jian YUAN ; Guohua ZENG ; Ming LEI ; Jintai LUO ; Ze ZHANG ; Weide ZHONG
Publication Type:Journal Article
Keywords: Ketamine; Bladder hydrodistention
From: Clinical Medicine of China 2012;28(7):746-748
CountryChina
Language:Chinese
Abstract: Objective To evaluate the efficacy and safety of bladder hydrodistention for the treatment of ketamine-associated bladder dysfunction.Methods Six patients were required to withdraw the ketamine and treated with bladder hydrodistention therapy and sodium hyaluronate irrigation,and medicine to pretect liver and kidney was also used.Results The biopsies of 6 cases demonstrated the cystitis through biopsy.Lower urinary tract symptoms such as urgency,thamuria and odynuria were significantly relieved after bladder installation within 30 days.The O'Leary-Sant ICSI scores and the ICPI scores reduced to 3.5 ± 1.6,2.8 ± 1.5 respectively.The functional bladder capacities increased to an anverage of (180 ± 28)ml,.2-3 times of nocturia,Qmax (14.4 ± 4.3) ml/s.All cases were followed up for 4 to 18 months.Symptoms disappeared or were significantly relieved in all patients.Conclusion Contracture of bladder might be the main presentation of ketamine-associated bladder dysfunction.Intravesical hydrodistention therapy and sodium hyaluronate irrigation could be the safe and effective therapy in the treatment of katamine-associated dysfunction.