Comparison of dexmedetomidine and propofol for stereotactic brain surgery in patients with intractable psychosis
10.3760/cma.j.issn.0254-1416.2012.06.029
- VernacularTitle:右美托咪啶和异丙酚用于难治性精神病患者脑立体定向手术麻醉效果的比较
- Author:
Gaoxiang WANG
;
Lianhua ZHANG
;
Hui ZHAO
;
Yuan WANG
;
Xude SUN
- Publication Type:Journal Article
- Keywords:
Dexmedetomidine;
Propofol;
Anesthesia,general;
Stereotaxic techniques
- From:
Chinese Journal of Anesthesiology
2012;32(6):749-751
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the effects of dexmedetomidine and propofol for stereotactic brain surgery in patients with intractable psychosis.MethodsThirty male patients with intractable psychosis,aged 22-33 yr,weighing 60-90 kg,scheduled for stereotactic surgery,were randomized to receive either propofol (group P,n =15) or dexmedetomidine (group D,n =15).Anesthesia was induced with iv injection of midazolam 0.05-0.10 mg/kg and fentany 1-2 μg/kg in the two groups,and in addition,dexmedetomidine was infused at 0.3-0.7μg· kg- 1 · h- 1 after a loading dose of 1 μg/kg (duration of infusion ＞ 10 min) and propofol 1-2 mg/kg was injected intravenously before endotracheal intubation in group D and propofol 2-3 mg/kg was injected intravenously and then propofol was infused at a rate of 3-4 mg· kg- 1 · h- 1 in group P.Orotracheal intubation was performed under the guidance of direct laryngoscope.The patients kept spontaneous breathing.The adverse events such as body movement,bucking,apnea,adverse cardiac events and hypoxemia were recorded during location.ResultsThe incidence of body movement,bucking,apnea,tachycardia,hypotension and hypoxemia was significandy lower,while the incidence of bradycardia was significantly higher in group D than in group P ( P ＜ 0.01 ).There was no significant difference in the incidence of hypertension between the two groups (P ＞ 0.05).ConclusionDexmedetomidine provides better anesthesia,exerts less effect on the respiratory and circulatory functions and is safer than propofol for stereotactic surgery in patients with intractable psychosis.
