Prognosis of gastric cancer in cirrhotic patients
10.3760/cma.j.issn.1007-631X.2012.07.018
- VernacularTitle:影响合并肝硬化胃癌患者预后的多因素分析
- Author:
Chi ZHANG
;
Xiang HU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Liver cirrhosis;
Prognosis;
Regression analysis
- From:
Chinese Journal of General Surgery
2012;27(7):572-575
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate prognostic factors for gastric cancer patients with liver cirrhosis.Methods The clinicopathological data of 52 gastric caner patients with liver cirrhosis operated on between March 1994 and March 2006 were analyzed retrospectively and the prognostic factors were evaluated.Significant factors were then entered into a Cox regression analysis.Results The postoperative 1-3- and 5- year survival rates for these 52 patients followed up were 78％,44％ and 33％.Univariate analysis revealed that age,Borrmann type,histology timue typing,tumor size,pTNM stage,Child-pugh grade,postoperative complications,ascites,and albumin level were statistical significance for survival rate (P ＜ 0.05 ).Multivariate analysis demonstrated that pTNM stage,Child-pugh grade,ascites were independent prognostic factors affecting prognosis( P ＜ 0.05 ).The risk of Child-pugh grade is 3.005,the risk of pTNM is 1.594.Conclusions Compared with pathological disease stage of the gastric cancer,liver function affects more on the prognosis of cirrhotic gastric cancer patients undergoing gastrectomy.In Child-pugh grade B or C cases,postoperative liver dysfunction was the main concern.While those of Child-pugh grade A should undergo standard D2 gastrectomy.
