Relationship between Ala 54 Thr polymorphism of intestinal fatty acid-binding protein 2 gene and plasma lipids in old population

VernacularTitle:老年人小肠脂肪酸结合蛋白基因54位密码子多态性与血脂水平的关系
Author: Xuewen GAO ; Yanhui ZOU ; Ping WANG ; Yali YUN
Publication Type:Journal Article
Keywords: Fatty acid-binding proteins; Polymorphism,single nucleotide; Lipid metabolism disorders
From: Chinese Journal of Geriatrics 2012;31(6):451-453
CountryChina
Language:Chinese
Abstract: Objective To investigate relationship between Ala 54 Thr polymorphism in the intestinal fatty acid-binding protein (I-FABP) and plasma lipids in old people.Methods We collected fasting blood samples of selected groups,then we extracted DNA from whole blood,and detected lipids from serum.The 54A/T I-FABP genotypes were analyzed in 72 Han Chinese elderly by polymerase chain reaction (PCR) and DNA restriction enzyming.Total cholesterol (TC),triglyceride (TG),high density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C) were detected.Genotype subgroups were Thr54 (-) and Thr54 (+) groups (36 cases for each).Results Compared with Thr54 (-) genotype group,Thr54 (+) genotype group had higher levels of plasma TC[(4.50±0.73) mmol/L vs.(5.48±0.49)mmol/L],TG[(1.08±0.48) mmol/L vs.(2.02±0.53)mmol/L],LDL-C [(3.10±0.44) mmol/L vs.(3.50±0.66)mmol/L],and had lower level of HDL-C [(1.14±0.25) mmol/L vs.(0.96±0.23)mmol/L](t=-6.67,-7.84,-3.03,3.05,all P＜0.05).