Influence of Amlodipine besylate/atorvastatin calcium on atherosclerosis level in elderly with hypertension and hyperlipemias
10.3760/cma.j.issn.0254-9026.2012.06.007
- VernacularTitle:氨氯地平阿伐他汀钙对老年高血压并存高脂血症患者动脉粥样硬化水平的影响
- Author:
An CHEN
;
Dongzhi WANG
;
Genghua XU
;
Jun WANG
;
Xiaojian TAO
;
Yibo WANG
;
Xiaocui YANG
;
Jie SONG
- Publication Type:Journal Article
- Keywords:
Hypertension;
Hyperlipidemia;
Atherosclerosis
- From:
Chinese Journal of Geriatrics
2012;31(6):469-471
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate influence of amlodipine /atorvastatin on atherosclerosis in the elderly with hypertension and hyperlipidemia.Methods Totally 108 cases with hypertension and hyperlipidemia in our hospital were randomly divided into control group and observation group (n =54 each).The control group received conventional antihypertensive treatment such as diuretics,angiotensin-converting enzyme inhibitors,calcium antagonists; the observation group received amlodipine and atorvastatin combination tablet as add-on therapy to the above drugs for 6 months.The blood lipid level and carotid artery ultrasound detection results were observed and compared between the two groups after treatment.Results The levels of TC[(4.23 ± 0.79)mmol/L vs.( 5.32 ±1.23)mmol/L],TG[(1.53±0.35) mmol/L vs.(5.32± 1.23) mmol/L],LDL-C [(3.19 ± 0.59)mmol/L vs.(4.07±0.79)mmo1/L]were decreased,while HDL-C [(1.53±0.95)mmol/L vs.(1.32±0.83)mmol/L]were increased in observation group after treatment as compared to control group (all P ＜0.05).After carotid artery ultrasonography,the LN[( 1.61± 0.76) scores vs.( 2.24 ± 0.89) scores ] and IMT [(0.76 ± 0.22)mm vs.(0.98 ± 0.28)mm] levels were lower in observation group after treatment than in control group (P＜0.05).Conclusions Amlodipine/atorvastatin combination can reduce blood lipids and alleviate atherosclerosis.It is suitable for elderly patients with hypertension and hyperlipidemia.
