Effects of dexmedetomidine on postoperative cognitive dysfunction in elderly patients undergoing laparoscopic radical trachelectomy

VernacularTitle:右美托咪啶对老年患者腹腔镜下宫颈癌根治术后早期认知功能的影响
Author: Mei FANG ; Zhihong DONG ; Bing ZHANG
Publication Type:Journal Article
Keywords: Dexmedetomin; Aged; Cognition disorders; Laparoscopy
From: Chinese Journal of Anesthesiology 2012;32(6):699-701
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the effects of dexmedetomidine on postoperative cognitive dysfunction (POCD) in the elderly patients undergoing laparoscopic radical trachelectomy.MethodsSixty ASA Ⅰ or Ⅱ patients (aged 65-80 yr and weighing 55-74 kg) undergoing elective laparoscopic radical trachelectomy were randomly divided into two groups:30 patients received intravenous injection of dexmedetomidine 0.2 μg · kg - 1 ·h- 1 ( group D EX) and 30 received same volume of normal saline (control group,group NS) after induction of anesthesia.Cognitive function was assessed at 1 day before operation and on the 7th day after operation using a battery of nine cognitive dysfunction tests.ResultsCompared with group NS,on the 7th postoperative day,the incidence of POCD was decreased in group DEX ( P ＜ 0.05 ).ConclusionDexmedetomidine can improve POCD in the elderly patients undergoing laparoscopic radicaltrachelectomy.