Expression and clinical significance of hepatocyte growth factor receptor and epidermal growth factor receptor in pancreatic cancer
10.3760/cma.j.issn.1007-8118.2012.06.015
- VernacularTitle:肝细胞生长因子受体和表皮生长因子受体在胰腺癌中的表达及临床意义
- Author:
Wei CHEN
;
Li HUANG
;
Yunpeng HUA
;
Shunli SHEN
;
Jiaming LAI
;
Baogang PENG
;
Lijian LIANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Proto-oncogene proteins c-met;
Receptor;
epidermal growth factor
- From:
Chinese Journal of Hepatobiliary Surgery
2012;18(6):447-451
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the clinical significance of hepatocyte growth factor receptor (Met) and epidermal growth factor receptor (EGFR) in the clinicopathology and prognosis of pancreatic cancer.Methods 70 patients admitted with pancreatic cancer from 1995 to 2005 were retrospectively analyzed with clinicopathological and follow-up data.Expression of Met and EGFR in cancer nest embedded with paraffin were detected by immunohislostaining (EnVision method) and correlation with clinicopathologic parameters and mutual correlation between these two receptors were further analyzed.Prognosis and related risk factors were analyzed by Kaplan-Meier survival analysis and Cox regression analysis,respectively.Results Both Met and EGFR significantly correlated with TNM staging,tumor size and superior mesenteric vessels invasion (P＜0.05).Expression level of Met positively correlated with that of EGFR (r9 =0.658,P＜0.05).Both Met and EGFR significantly correlated with patients' survival (P＜0.05) and Met was an independent prognostic risk factor for pancreatic cancer.Conclusions Both Met and EGFR significantly affect development and prognosis of pancreatic cancer and correlate with each other.Simultaneously targeting both Met and EGFR pathways may provide an advisable strategy of targeted therapy in pancreatic cancer.
