Study on the association of apoptosis-related molecule serum-soluble Fas with incomplete Kawasaki disease
10.3760/cma.j.issn.1008-1372.2012.06.004
- VernacularTitle:凋亡相关分子血清可溶性Fas与不完全川崎病的关联研究
- Author:
Haiyan QIU
;
Yazhen DI
;
Ting CAI
;
Yunyan LI
;
Ling WU
;
Shirong QIN
;
Yihong FENG
;
Yahong LIN
- Publication Type:Journal Article
- Keywords:
Mucocutaneous lymph node syndrome/metabolism;
Antigens,CD95/blood;
Child
- From:
Journal of Chinese Physician
2012;14(6):732-735
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo compare the levels of sFas in the sera among Kawasaki disease (KD),incomplete Kawasaki disease (IKD),and normal control groups,and to analyze the relationship of sFas with IKD children.MethodsA total of 32 cases of acute KD and acute IKD children,and 20 cases of the control children were selected,respectively.The levels of serum sFas among three groups were measured using ELISA kits.Each child among the three groups was examined by echocardiography.Results(1)The levels of serum sFas among the three groups were[ (0.54±0.20)ng/L in KD,(0.55±0.16)ng/L in IKD,and (0.24 ± 0.04) ng/L] in control group,respectively.The overall means of sFas in the KD and IKD groups were higher than the control group,and the differences were statistically significant( F=29.276,P＜0.05 ).(2)The levels of serum sFas among echocardiography abnormal and normal groups were[ (0.65±0.19) ng/L and (0.49±0.10)ng/L],respectively; and the difference between two groups were statistically significant ( t=3.139,P ＜ 0.05 ).ConclusionsThe expression levels of sFas in the peripheral serum of IKD children were increased,and there was a close association of overexpression of sFas with the cardiovascular damage in IKD children.
