Analysis of serum matrix metalloproteinase-7 for diagnosis and prognosis in patients with bladder cancer
10.3760/cma.j.issn.1008-1372.2012.06.006
- VernacularTitle:血清基质金属蛋白酶7与膀胱癌的诊断及预后关系分析
- Author:
Daye CHENG
;
Yunhui LI
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase 7/blood;
Urinary bladder neoplasms/metabolism/pathology
- From:
Journal of Chinese Physician
2012;14(6):739-741
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveThe aim of this study is to evaluate diagnostic and prognostic value of matrix metalloproteinase-7 (MMP-7) in patients with bladder cancer.MethodsA total of 77 patients with bladder cancer and 65 healthy controls were recruited in this study.The levels of serum MMP-7 were measured by ELISA methods.ResultsThe level of serum MMP-7 in bladder cancer group was significantly higher than those in the healthy control [ [ 3.1 (0 - 32.1 ) ng/ml vs 1.0 ( 0.2 - 2.6) ng/ml,x2 =9.29,P <0.01 ].The level of serum MMP-7 was correlated to lymph node metastasis ( x2=10.49,P < 0.01 ) and tumor grade ( x2=4.55,P =0.033 ).Receiver operating characteristic ( ROC ) curves of serum MMP-7level was 0.810.Serum MMP-7 was used to diagnose bladder cancer with the sensitivity of 83.6% and specificity of 77.4%.The survival rate in patients with a high level of MMP-7 was lower than that with a low level of MMP-7 (x2=3.88,P =0.0488).ConclusionsMMP-7 may be closely associated with the progression of bladder cancer.Serum MMP-7 may be a useful index for diagnosis and prognosis for patients with bladder cancer.