Comparison of effects of anesthesia induction with different anesthetics on intraocular pressure
10.3760/cma.j.issn.0254-1416.2012.05.005
- VernacularTitle:不同麻醉诱导对患者眼内压影响的比较
- Author:
Jianping JIANG
;
Wenfeng FAN
;
Donghai ZHONG
;
Zhirui LI
;
Zhixian MO
- Publication Type:Journal Article
- Keywords:
Intraocular pressure;
Propofol;
Midazolam;
Etomidate;
Anesthesia,general
- From:
Chinese Journal of Anesthesiology
2012;32(5):538-540
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of propofol,nidazolarm versus etomidate combined with sufentanil for anesthesia induction on intraocular pressure.Methods Forty-five ASA Ⅰ or Ⅱ patients,aged 20-40 yr,scheduled for surgery under general surgery,were randomly divided into 3 groups(n =15 each):propofol group(group P); midazolam group(group M)and etomidate group(group E).Anesthesia was induced with iv injection of propofol 2 mg/kg,midazolam 0.2 mg/kg,and etomidate 0.3 mg/kg in P,M and E groups respectively,and then with iv injection of sufentanil 0.2 μg/kg and cisatracurium 0.2 mg/kg in all the groups.The patients were then tracheal intubated.Intraocular pressure(IOP)and MAP were recorded at 1 m in before induction of anesthesia (T0),before intubation(T1),and at 0,1 and 2 min after intubation(T2-4).Results Compared with group P,the incidence of intraocujar hypotension was significantly decreased in group M(P ＜ 0.01).Compared with group E,the incidence of intraocular hypertension was significantly decreased in P and M groups(P ＜ 0.05),The correlation coefficient between MAP and IOP was 0.831,0.889 or 0.806 in group P,M or E respectively(P ＜0.05),and there was no significant difference in the correlation coefficient among the three groups(P ＞ 0.05).Conclusion Midazolam combined with sufentanil for anesthesia induction exerts less influence on lOP and the degree of MAP fluctuations is a major factor contributing to the change in IOP.
