Effects of mannitol on erythrocyte aldose reductase activity, plasma nitric oxide and malondialdehyde concentrations in patients undergoing hepatolobectomy
10.3760/cma.j.issn.0254-1416.2012.05.007
- VernacularTitle:甘露醇对肝叶切除术患者红细胞醛糖还原酶、血浆一氧化氮和丙二醛水平的影响
- Author:
Canqin WANG
;
Zhongyun WANG
;
Yinbing PAN
- Publication Type:Journal Article
- Keywords:
Mannitol;
Hepatectomy;
Aldehyde reductase;
Erythrocytes;
Nitric oxide;
Malondialdehyde
- From:
Chinese Journal of Anesthesiology
2012;32(5):545-547
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of mannitol on the activity of erythrncyte aldose reduclase (AR),plasma nitric oxide(NO)and malondialdehyde(MDA)concentrations in patients undergoing hepatolobectomy.Methods Forty ASA Ⅰ or Ⅱ patients(aged 24-63 yr and weighing 50-68 kg),receiving combined general and epidural anesthesia and undergoing selective hepatolobectomy,were randomly assigned into a mannitol group (group M)and a normal saline group(group C).During hepatic portal occlusion,normal saline 1.5 ml/kg and 20％ mannitol 1.5 ml/kg were intravenously infused in groups C and M respectively for 30 min.Venous blood samples were collected to measure the erythrocyte AR activity and plasma NO and MDA concentrations at the following time points:before anesthesia induction(T0),at the end of hepatic portal occlusion(T1),at the end of operation(T2),one day after operation(T3)and three days after operation(T4),respectively.Results Compared with group C at T1,2,the erythrocyte AR and plasma MDA concentration decreased while plasma NO concentration increased in group M(P ＜ 0.05).Conclusion Mannitol can reduce hepatic ischemia and reperfusion injury in patients undergoing hepatolobectomy,which may be related to the mechanism of mannitol removing oxygenderived free radicals and inhibiting lipid peroxidation.
