Neuroprotective effects of peroxisome proliferators-acfivated receptor γ ligand thiazolidinediones in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2012.05.011
- VernacularTitle:过氧化物酶体增殖物激活受体γ配体噻唑烷二酮类在脑缺血中的神经保护作用
- Author:
Ruiguan LIU
;
Guinan BI
- Publication Type:Journal Article
- Keywords:
PPAR γ;
Thiazolidinediones;
Thiadiazoles;
Brain Ischemia;
Neuroprotective Agents
- From:
International Journal of Cerebrovascular Diseases
2012;20(5):372-377
- CountryChina
- Language:Chinese
-
Abstract:
Thiazolidinodiones are a synthetic ligand of peroxisome proliferator-activated receptor γ(PPARγ).PPARγhas certain protective effects for several types of tissues.The research covers the areas of glucose,lipid metabolism,cancer and atherosclerosis,etc.At present,the roles of thiazolidinediones in central nervous system diseases have received much attention,such as cerebral infarction,multiple sclerosis,and Alzheimer's disease.This article reviews the effects of PPARγ ligand thiazolidinediones on inhibiting the proliferation of glial cells,promoting angiogenesis,and antagonizing neuronal apoptosis after cerebral ischemia.
