Roles of glycogen synthase kinase 3β signaling pathway in cerebral ischemia
10.3760/cma.j.issn.1673-4165.2012.05.013
- VernacularTitle:糖原合酶激酶3β信号通路在脑缺血中的作用
- Author:
Jiaoyue HU
;
En XU
- Publication Type:Journal Article
- Keywords:
Glycogen Synthase Kinase 3;
Brain Ischemia;
Ischemic Preconditioning
- From:
International Journal of Cerebrovascular Diseases
2012;20(5):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Glycogen synthase kinase 3β (GSK3β) is a serine/threonine kinase.Several signaling pathways,such as growth factors and Wnts,inhibit the GSK3β activity,thereby it promotes cell survival At the time of cerebral ischemia,with the changes of the phosphorylated GSK3β level,its upstream and downstream phosphorylation levels also change.Ischemic preconditioning and postconditioning may induce cerebral ischemic tolerance by regulating the GSK3β signaling pathway.
