The roles of ubiquitin-proteasome inhibitor in atherosclerosis
10.3760/cma.j.issn.1673-4165.2012.05.014
- VernacularTitle:泛素-蛋白酶体抑制剂在动脉粥样硬化中的作用
- Author:
Haimei FAN
;
Yuee SHEN
;
Kun LI
;
Ruihong SUN
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Ubiquitin;
Ubiquitin-Protein Ligase Complexes
- From:
International Journal of Cerebrovascular Diseases
2012;20(5):389-393
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis (AS) is a common underlying disease that hazard to human health.It is closely associated with stroke,hypertension,coronary artery disease,and diabetes.AS on the premise of vascular intimnal injury,excessive smooth muscle cell proliferation,inflammatory cell infiltration,oxidative stress,apoptosis and other mschanisms participate together.In eucaryotic organisms,most proteins are degraded by ubiquitin-proteasome system (UPS).An increasing number of evidence indicates that UPS is associated with the occurrenee and development of AS and complications.This article reviews the relationship between.UPS and AS,as well as the effect of ubiquitin-proteasome inhibitor on AS.
