The long-term efficacy and safety of rituximab combined with cyclophosphamide in treatment of seven patients with refractory and recurrent autoimmune hemolytic anemia
10.3760/cma.j.issn.0578-1426.2012.06.014
- VernacularTitle:利妥昔单抗联合环磷酰胺治疗七例难治性自身免疫性溶血性贫血的长期疗效和安全性
- Author:
Hong LIU
;
Limin XING
;
Huaquan WANG
;
Yuhong WU
;
Wen QU
;
Yong LIANG
;
Guojin WANG
;
Jia SONG
;
Xiaoming WANG
;
Jing GUAN
;
Lijuan LI
;
Rong FU
;
Zonghong SHAO
- Publication Type:Journal Article
- Keywords:
Anemia,hemolytic,autoimmune;
Treatment outcome;
Rituximab;
Cyclophosphamide
- From:
Chinese Journal of Internal Medicine
2012;51(6):456-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the efficacy and safety of monoclonal antibody rituximab combined with cyclophosphamide (CTX) in the treatment of refractory and recurrent autoimmune hemolytic anemia.Methods Seven cases with refractory and recurrent autoimmune hemolytic anemia ( including 1 case of Evans syndrome) were recruited during January,2007 to December,2010.Treatment regimens were as follows:rituximab:375 mg/m2,1 time/week,2-6 courses; CTX:1 g,1/10 d,2-7 courses; combined with intravenous immunoglobulin (IVIG) 5 g,1 time/week,given 1 day after rituximab administration.The efficacy and safety of this regimen were assessed during follow-up.Results All the patients showed good responses (7/7).Six patients achieved complete remission (6/7) and one achieved partial remission ( 1/7 ).Average follow-up time for the patients was 27 months.All patients remained in remission during the 12-month follow-up visits.Two patients showed elevated indirect bilirubin and increased reticulocyte counts within 24 months.One patient achieved complete remission after additional rituximab therapy,and another patient remained partial remission after cyclosporine therapy.At the time of 36-month follow-up visit,the patient relapsed and was retreated with 3 courses of rituximab combined with CTX and eventually achieved partial remission.All patients tolerated the treatment well with few mild side effects.Conclusions Rituximab combined with CTX is effective and relatively safe in patients with refractory and recurrent autoimmune hemolytic anemia.Additional treatment to relapse patients about 12-24 months after drug withdrawal continues to be effective.
